Florida party girl Rex (Roberts) turns out to be the only hope for the NASA space program after a fluke puts her in training with other candidates who may have better resumes, but don't have her smarts, heart and moxie.
影片改编自同名畅销童书《Clifford the Big Red Dog》,讲述在纽约,小女孩Emily Elizabeth(达比·坎普 饰)得到了一条小狗,这只名叫克里弗的红色狗子乖巧可爱,成为了在学校不合群、孤独的她的好朋友。但狗狗慢慢长成了庞然大物,被一家生物基因公司看上了,Emily和叔叔Casy(杰克·怀特霍尔 饰)必须带着它逃开贪婪之人的追捕。